Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 98, No. 12, 2019, pp.1769-1776
Published online, 26th December, 2019
DOI: 10.3987/COM-19-14193
Studies toward Identifying the Pharmacophore of L-755,807 for Amyloid-β Aggregation Inhibitory Activity

Kenichi Kobayashi,* Kosaku Tanaka III, Yusuke Honma, Momoko Suzuki, and Hiroshi Kogen*

*Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


To investigate the structure–activity relationship of L-755,807 for amyloid-β aggregation inhibitory activity, L-755,807 analogs were synthesized and biologically evaluated. The results suggest that a hydrophobic conjugated carbon chain with a terminal hydrophilic functional group is essential for the potent activity. These findings provide a starting point for identifying the pharmacophore of L-755,807.