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Short Paper | Regular issue | Vol 98, No. 11, 2019, pp.1574-1579
Published online, 13th November, 2019
DOI: 10.3987/COM-19-14164
Isochromophilol A, a New Azaphilone Isolated from Penicillium sp. RO369, a Leaf Litter Inhabiting Fungus from Tsuga diversifolia

Kan'ichiro Ishiuchi,* Dai Hirose, Yoriko Takahashi, Ryu Miyagawa, Kohei Watanabe, and Susumu Kitanaka*

*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-Dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan


A new sclerotiorin-type azaphilone, isochromophilol A (1), was isolated from Penicillium sp. RO369 associated with Tsuga diversifolia, along with eight known compounds (29). The structure of 1 was elucidated on the basis of spectroscopic data. Isochromophilol A (1) (16 μg) showed weak anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with an inhibition diameter of 8.8 ± 1.0 mm