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Review | Regular issue | Vol 98, No. 10, 2019, pp.1309-1344
Published online, 29th October, 2019
DOI: 10.3987/REV-19-914
Recent Advances in Transition-Metal-Catalyzed Synthesis of 3- and/or 4-Aryl-2(1H)-Quinolones

Yoshihiko Yamamoto*

*Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan


2(1H)-Quinolone is a privileged nitrogen heterocycle that is found in various bioactive compounds and functional molecules. In particular, derivatives possessing aryl substituents at the 3- and/or 4-positions are significant synthetic targets as they are promising drug leads. This review surveys the synthetic methods for 3- and/or 4-aryl-2(1H)-quinolones that involve transition-metal-catalyzed construction of the 2(1H)-quinolone framework. Transition-metal-catalyzed arylations of 2(1H)-quinolone scaffolds are also surveyed.