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Paper | Regular issue | Vol 98, No. 10, 2019, pp.1375-1383
Published online, 4th October, 2019
DOI: 10.3987/COM-19-14151
The One-Pot Synthesis of Pyridine Derivatives from The Corresponding 1,5-Dicarbonyl Compounds

Hiromichi Mihara, Takeru Miyakoshi, Yui Kikuchi, and Hiroyuki Konno*

*Graduate School of Science and Engineering, Yamagata University, 3-16 Jonan 4-Chome, Yonezawa 992-8510, Japan


The optimization of the one-pot, acid-promoted synthesis of pyridine and alkylpyridine derivatives from simple alkyl-1,5-dicarbonyl derivatives and via the corresponding oxime intermediate is described. Of all the combinations of acids and solvents tested, the use of HCl in refluxing dioxane was found to result in the highest chemical yields. Twelve pyridines were prepared using this method.