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Short Paper | Regular issue | Vol 98, No. 10, 2019, pp.1437-1444
Published online, 17th October, 2019
DOI: 10.3987/COM-19-14142
Anti-Tmv Isoquinoline Alkaloids from The Whole Plants of Thalictrum glandulosissimum

Chun-Man Song,* Guang-Hui Kong, Yu-Ping Wu, Eric Yin, Bradley Liu, Zhen-Yuan Xia, Hai-Tao Huang, Guang-Yu Yang, and Qiu-Fen Hu*

*Chemistry, Cyats, Keyi Rd 653100, China


Three new (1-3), together with three known (4-6) isoquinoline alkaloids were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (Anti-TMV) activity. The results revealed that compounds 2, 3 and 4 showed potential anti-TMV activities with inhibition rates of (35.6±3.5)%, (36.2%±3.8)%, (46.3%±3.2)%, at the concentration of 20 µM, respectively. These rates are higher than that of positive control.