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Short Paper | Regular issue | Vol 98, No. 8, 2019, pp.1142-1154
Published online, 19th August, 2019
DOI: 10.3987/COM-19-14137
An Ionic Liquid-Based Green Synthesis Strategy: Synthesis of Dihydropyrimidinones by Three-Component Biginelli-Type Reaction of Aliphatic Aldehydes, Aromatic Aldehydes and Urea

Lei-Han Fu, Zong-Bo Xie,* Guo-Qing Chen, Jin Lan, Zhi-Yu Hu, and Zhang-Gao Le*

*Department of Applied Chemistry, East China University of Technology, Guanglan Road 330013, China

Abstract

A Biginelli-type reaction involving aliphatic aldehydes, aromatic aldehydes, and urea was performed at high concentration with high regioselectivity to give a range of highly diverse 3,4-dihydropyrimidin-2-(1H)-one products in 58-88% yields, where a 30% aqueous solution of ionic liquid (1-ethyl-3-methylimidazolium tetrafluoroborate) was employed as a green reaction medium. The catalyst can be easily recycled and reused with similar efficacy for at least four cycles.