Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 98, No. 8, 2019, pp.1130-1141
Published online, 13th August, 2019
DOI: 10.3987/COM-19-14128
Synthesis and the First Structure–Activity Relationship Study of Imidazole Alkaloid from Red Ascidian as Aldose Reductase Inhibitors

Kenta Morikawa, Sota Uno, Shoko Higashi, Masaru Goto, and Ryota Saito*

*Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan


We synthesized a series of 2-aroyl-4-aryl-1H-imidazoles (2 and 3) and evaluated their in vitro AR inhibitory activity for the first time. We observed improved activities with derivatives having multiple catechol moieties.