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Short Paper | Regular issue | Vol 98, No. 11, 2019, pp.1555-1562
Published online, 30th October, 2019
DOI: 10.3987/COM-19-14166
Facile Synthesis of (Guaiazulen-1-yl)-1H-pyrroles via Paal-Knorr Reaction

Lu Zhang, Dao-Lin Wang,* Jin-Juan Xing, and Lin Liu

*College of Chemistry and Chemical Engineering, Bohai University, 19, Keji Rd., New Songshan District, Jinzhou City, Liaoning Province 121001, China


An efficient and simple method for the synthesis of (guaiazulen-1-yl)-1H-pyrroles was described. The construction of this new heteroarylazulene system was achieved by a the Paal-Knorr reaction of 3-acetyl-4-(guaiazulen-1-yl)hexane- 2,5-dione (4), easily preparation by a three-component condensation of guaiazulene (1), methylglyoxal (2) and acetylacetone (3), with primary amines (5).