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Short Paper | Regular issue | Vol 98, No. 8, 2019, pp.1119-1129
Published online, 30th July, 2019
DOI: 10.3987/COM-19-14114
Environmentally Friendly Synthesis of N-Methylated Nitrogen Heterocycles from an Aqueous Solution of Methylamine and Diols

Akane Enomoto, Takuya Shimbayashi, and Ken-ichi Fujita*

*Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan


N-Methylated nitrogen heterocycles are important compounds which are very common in organic, pharmaceutical, and material chemistry. Development of new environmentally friendly catalytic methods for the synthesis of N-methylated heterocycles using cost-effective and readily-available starting materials is strongly demanded. Herein, we report the efficient synthesis of N-methylated heterocycles using readily-available aqueous solution of methylamine and various diols catalyzed by iridium complexes. This catalytic system is attractive because of its high atom economy exhausting water as a sole by-product.