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Short Paper | Regular issue | Vol 98, No. 11, 2019, pp.1547-1554
Published online, 25th November, 2019
DOI: 10.3987/COM-19-14165
One-Pot Synthesis of 3-(Guaiazulen-3-yl)dihydro-1H- indol-4(5H)-ones via Domino Reaction

Lu Zhang, Dao-Lin Wang,* Jin-Juan Xing, and Lin Liu

*College of Chemistry and Chemical Engineering, Bohai University, 19, Keji Rd., New Songshan District, Jinzhou City, Liaoning Province 121001, China


A facile and efficient one-pot procedure for the preparation of 3-(guaiazulen-1-yl)dihydro-1H-indol-4(5H)-ones by a catalyst-free, three- component reaction of guaiazulene, methylglyoxal and enaminones under mild conditions in good yield is reported.