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Paper | Regular issue | Vol 98, No. 9, 2019, pp.1189-1199
Published online, 20th September, 2019
DOI: 10.3987/COM-19-14113
Functionalization of Benzylic sp3 C-H of 2-Methylazaarenes in Deep Eutectic Solvent

Guo-Qing Chen, Zong-Bo Xie,* Feng Ai, Zhong-Sheng Chen, Jin Lan, Zhi-Yu Hu, and Zhang-Gao Le*

*Department of Applied Chemistry, East China University of Technology, Guanglan Road 330013, China


The catalyst-free addition of 2-methylazaarene benzylic sp3 C-H to electron-deficient olefins in deep eutectic solvents is reported. Moderate to good yields were obtained in 2 h at 80 °C in deep eutectic solvents. The method was operationally easy and involved mild reaction conditions. This expands the application of deep eutectic solvent in sp3 C-H functionalization reaction.