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Review | Regular issue | Vol 98, No. 5, 2019, pp.621-635
Published online, 25th April, 2019
DOI: 10.3987/REV-19-908
Recent Application of ortho-Quinodimethane Chemistry for Synthesis of Heterocyclic Compounds

Yuji Matsuya*

*Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan


The o-quinodimethanes, generated by concerted 4π-electrocyclic ring-opening of benzocyclobutenes, have been widely utilized as a powerful intermediate for the construction of various fused-cyclic frameworks. In this review, recent applications for the construction of heterocycles as well as their biological aspects are surveyed.