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Short Paper | Regular issue | Vol 98, No. 5, 2019, pp.703-710
Published online, 26th April, 2019
DOI: 10.3987/COM-19-14073
Isobenzofuranone Derivatives from the Roots of Phlomis betonicoides and Their Bioactivity

Mu-Yao Li, Ling-Min Liao, Qi-Yan Sun, Dong Miao, Min Zhou, Yan-Qing Ye, Yi-Jian Chen, Qiu-Fen Hu,* and Wei-Guang Wang*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, Kunming 650031, China


Three new (1-3) together with three known (4-6) isobenzofuranone derivatives, were isolated from the roots of Phlomis betonicoides. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-6 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1-6 showed weak inhibition with diameter of inhibition zone of (IZD) of 9.2±1.2, 8.6±1.5, 9.8±1.6, 11.4±1.2, 8.2±1.0 and, 11.6±1.3 mm, respectively. Compounds 1-6 were also tested for the antioxidant activity, and they showed good antioxidant activity with an IC50 value of 4.6±0.8, 4.4±0.6, 4.0±0.6, 4.2±0.7, 4.8±0.6, and 4.1±0.5 μg/mL, respectively.