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Short Paper | Regular issue | Vol 98, No. 5, 2019, pp.681-692
Published online, 23rd April, 2019
DOI: 10.3987/COM-19-14062
Reaction of 2-Imino-2H-chromene-3-carboxamide with Phosphorus Halides: Synthesis of Some Novel Chromeno[2,3-d][1,3,2]diazaphosphinines and Chromeno[4,3-c][1,2]azaphosphole and Their Antioxidant and Cytotoxicity Properties

Tarik E. Ali,* Mohammed A. Assiri, Hafez M. El-Shaaer, Ahmed M. Fouda, Mohamed M. Hassan, and Noha M. Hassanin

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt


Novel 1,2-azaphosphole and 1,3,2-diazaphosphinines containing a chromene ring have been obtained from the treatment of 2-imino-2H-chromene-3-carboxamide (1) with some phosphorus halides. The compounds were evaluated for antioxidant and cytotoxic activities. Among the synthesized compounds, compound 4 exhibited the most potent antioxidant agents in comparison with ascorbic acid as standard antioxidant. Also, compound 4 recorded potentially cytotoxicity against all four cell lines.