Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 98, No. 5, 2019, pp.681-692
Published online, 23rd April, 2019
DOI: 10.3987/COM-19-14062
Reaction of 2-Imino-2H-chromene-3-carboxamide with Phosphorus Halides: Synthesis of Some Novel Chromeno[2,3-d][1,3,2]diazaphosphinines and Chromeno[4,3-c][1,2]azaphosphole and Their Antioxidant and Cytotoxicity Properties

Tarik E. Ali,* Mohammed A. Assiri, Hafez M. El-Shaaer, Ahmed M. Fouda, Mohamed M. Hassan, and Noha M. Hassanin

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt

Abstract

Novel 1,2-azaphosphole and 1,3,2-diazaphosphinines containing a chromene ring have been obtained from the treatment of 2-imino-2H-chromene-3-carboxamide (1) with some phosphorus halides. The compounds were evaluated for antioxidant and cytotoxic activities. Among the synthesized compounds, compound 4 exhibited the most potent antioxidant agents in comparison with ascorbic acid as standard antioxidant. Also, compound 4 recorded potentially cytotoxicity against all four cell lines.