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Short Paper | Regular issue | Vol 98, No. 5, 2019, pp.674-680
Published online, 25th April, 2019
DOI: 10.3987/COM-19-14059
Practical Synthesis of Pimobendan

Ping Zou, Lin Hu, Xi-Meng Yan, Xiao-Yue Li, Wanguo Wei, Xiao-Long Qiu,* and Shao-Hua Gou*

*Wisdom Pharmaceutical Co. Ltd., No. 18, Qinghua Road, Haimen, Jiangsu, 226123, China


Pimobendan is a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects. Several attempts have been made to synthesize this drug. In this work, a facile synthetic route for the preparation of pimobendan from readily available starting materials and easily handled reagents is provided.