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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Short Paper | Regular issue | Vol 98, No. 5, 2019, pp.674-680
Published online, 25th April, 2019
Published online, 25th April, 2019
DOI: 10.3987/COM-19-14059
■ Practical Synthesis of Pimobendan
Ping Zou, Lin Hu, Xi-Meng Yan, Xiao-Yue Li, Wanguo Wei, Xiao-Long Qiu,* and Shao-Hua Gou*
*Wisdom Pharmaceutical Co. Ltd., No. 18, Qinghua Road, Haimen, Jiangsu, 226123, China
Abstract
Pimobendan is a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects. Several attempts have been made to synthesize this drug. In this work, a facile synthetic route for the preparation of pimobendan from readily available starting materials and easily handled reagents is provided.
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