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Paper | Regular issue | Vol 98, No. 4, 2019, pp.509-518
Published online, 27th March, 2019
DOI: 10.3987/COM-19-14058
Diastereoselective Synthesis of 3-Alkylindoloquinolizine Derivatives via Regiospecific Oxidative Cyclization

Susana Morales-Barba, Joel L. Terán, Dino Gnecco, María L. Orea, David M. Aparicio, Víctor Gómez-Calvario, and Jorge R. Juárez*

*Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Edif. IC8, Ciudad Universitaria 72570, Mexico


3-Alkylindoloquinolizine alkaloids were synthetized in two steps from enantiopure 3-alkylpiperidines through sequential N-alkylation and regiospecific and diastereoselective oxidative cyclization.