Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 101, No. 2, 2020, pp.407-416
Published online, 24th July, 2019
DOI: 10.3987/COM-19-S(F)22
One-Pot Synthesis of 9-Spirofluorenes via Tandem Copper-Catalyzed Arylative Cyclization and Spirocyclization of Biaryl-Substituted Alkynyl Alcohols

Noriko Okamoto, Takuya Sueda, and Reiko Yanada*

*Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima, 737-0112, Japan


A tandem copper-catalyzed arylative cyclization and spirocyclization strategy to access spiro cyclic compounds is described. This method enables the one-pot construction of 9-spirofluorenes from readily available alkynyl alcohols with biaryl-substituents via the copper-catalyzed arylative ring-closing reaction and the Friedel–Crafts reaction.