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Short Paper | Regular issue | Vol 98, No. 4, 2019, pp.544-550
Published online, 28th March, 2019
DOI: 10.3987/COM-19-14044
Synthesis of N-alkyl Substituted Azasugar-tetrazole Hybrid Molecules via Ugi-azide Reaction

Hairong Luo,* Bangjian Xu, Lingyu Zhang, and Meihang Chen

*College of Material and Chemical Engineering, Tongren University, Tongren,Guizhou 554300, China

Abstract

An effective and facile method for the synthesis of N-alkyl substituted azasugar-tetrazole hybrid molecules is described. The one-pot Ugi-azide reaction provides convenient access to synthesis of α-tetrazolyl azasugar scaffolds as potential glucosidase inhibitors in moderate to good yields in methanol catalyst by lewis acid under mild conditions.