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Short Paper | Regular issue | Vol 98, No. 4, 2019, pp.535-543
Published online, 25th March, 2019
DOI: 10.3987/COM-18-14029
An Efficient Synthesis of N-Aryl-2-(indol-3-yl)acetamides via Multi-Component Reactions

Guo-Ning Zhang, Mengye Zhang, Xiaonan Du, Mei Zhu, Juxian Wang,* Daqing Shi,* and Yucheng Wang*

*Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

Abstract

An efficient synthesis of N-aryl-2-(indol-3-yl)acetamide derivatives via a four-component reaction of arylglyoxal monohydrate, Meldrium’s acid and anilines under microwave irradiations is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and materials available.