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Review | Regular issue | Vol 98, No. 2, 2019, pp.175-203
Published online, 22nd February, 2019
DOI: 10.3987/REV-18-901
Advances in the Synthesis of 1,2,4-Triazolo[1,5-a][1,3,5]triazines (5-Azapurines) and Their Biological Activity

Koon Kee Kow and Anton V. Dolzhenko*

*School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia

Abstract

The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton