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Paper | Regular issue | Vol 98, No. 1, 2019, pp.63-77
Published online, 21st January, 2019
DOI: 10.3987/COM-18-14019
Synthesis of 4,4-Dimethyl-2-(2-pyrrolyl)-2-oxazolines

Kentaro Okano,* Kazuki Morii, Daichi Mari, and Atsunori Mori

*Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan


A practical synthesis of 4,4-dimethyl-2-oxazolines on pyrrole was achieved via the cyclization of the corresponding amides, which were derived from the trichloroacetylpyrroles. The established conditions were applicable to pyrroles bearing a ketone or an ester moiety. In addition to pyrroles, the method could be extended to the synthesis of the indole derivative.