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Paper | Regular issue | Vol 98, No. 2, 2019, pp.205-214
Published online, 1st February, 2019
DOI: 10.3987/COM-18-14015
Bis-Heterocycles. Part II. Tetrahydro-3,3'-bi(1,2,4,5-oxatriazines)

Mustafa M. El-Abadelah, Firas F. Awwadi, Monther S. Zreid, and Mohammed M. Abadleh*

*Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, University of Petra, Amman 11196, Jordan

Abstract

A new set of tetrahydro-3,3'-bi(1,2,4,5-oxatriazines) 3a-e has been prepared via condensation reaction of alkanone- and cycloalkanone N-methylhydrazones with bis-nitrile oxide. Structures of the synthesized bis-heterocycles are based on IR, NMR and MS spectral data and further confirmed by single-crystal X-ray diffraction analysis for compounds 3a and 3d. Compound 3c exhibited inhibitory activity against butyrylcholinesterase (BChE) with IC50 = 1.75 × 10-5 μM.