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Short Paper | Regular issue | Vol 98, No. 1, 2019, pp.96-104
Published online, 21st January, 2019
DOI: 10.3987/COM-18-14010
Divergent Synthesis of 5,6- and 3,6-Dihydropyridin-2(1H)-one via Intramolecular Knoevenagel Condensation

Arturo Bocardo-Bautista, María L. Orea, Jorge R. Juárez, Dino Gnecco, David M. Aparicio,* and Joel L. Terán*

*Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Edif. IC9, Complejo de Ciencias, C.U. 72570 Puebla, Pue., México.


A simple and friendly strategy for the regioselective synthesis of 5,6- and 3,6-dihydropyridin-2(1H)-one via intramolecular Knoevenagel condensation from a common methyl 3-((2-(1,3-dioxolan-2-yl)ethyl)alkylamino)-3-oxopropanoate under acidic conditions is reported.