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Short Paper | Regular issue | Vol 96, No. 11, 2018, pp.1977-1990
Published online, 20th November, 2018
DOI: 10.3987/COM-18-13990
An Efficient Synthesis and Evaluation of Antitumor Activities of Functionalized Pyrano[2,3-b]quinolines

Wei Lin, Mengye Zhang, Ning Wang, Wentao Xu, and Daqing Shi*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China

Abstract

An efficient synthesis of novel functionalized pyrano[2,3-b]quinoline derivatives via a three-component reaction of 2-chloroquinoline-3-carbaldehydes, malononitrile and 1,3-dicarbonyl compounds under microwave irradiation is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. All of these compounds were evaluated for their antiproliferative properties in vitro against hepatic carcinoma cells and several compounds were found to have good activities.