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Short Paper | Regular issue | Vol 96, No. 11, 2018, pp.1991-1998
Published online, 15th November, 2018
DOI: 10.3987/COM-18-13991
A Pair of New Non-glycosidic Iridoid Epimers from Scrophularia ningpoensis

Wei Zhang, Peng Liu, Xin-Yu Ji, Xiang-Yang Chen, Yan-Yan Jiang, and Bin Liu*

*School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

Abstract

A pair of new non-glycosidic iridoid epimers, ningpogenins A and B (1a/1b), together with eighteen known ones (2-19) were isolated from the roots of Scrophularia ningpoensis. Their structures were elucidated by spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS. Compound 1 is an unusual example of natural ningpogenin—L-pyroglutamic adducts. In addition, the cytotoxic effects of the new compound against HepG2, U251 and SH-SY5Y cell lines were evaluated.