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Paper | Regular issue | Vol 96, No. 11, 2018, pp.1897-1909
Published online, 15th November, 2018
DOI: 10.3987/COM-18-13969
Synthesis, Characterization and Antimicrobial Evaluation of Some Novel Fused Pyrimido[1,2-b][1,2,4]triazine, Triazino[2,3-a]quinazoline and Imidazo[1,2-b][1,2,4]triazine Derivatives

Khaled S. Mohamed* and Elsherbiny H. El-Sayed

*Engineering Chemistry Department, Higher Institute for Engineering and Technology, New Damietta, Egypt


A novel pyrimido[1,2-b][1,2,4]triazine derivatives were synthesized by allowing 3-amino-1,2,4-triazine (1) to react with different reagents such as enaminone, enaminonitriles, 3-bromopropanenitile, 2-(2,5-dimethoxybenzylidene)malononitrile and 1,3-dicarbonyl compounds. Moreover, triazino[2,3-a]quinazoline derivatives were synthesized by reaction of 1 with 2-((dimethylamino)methylene)-5,5-dimethylcyclohexane-1,3-dione (18) and 2,6-bis(pyridin-3-ylmethylene)cyclohexan-1-one (20). On the other hand, treatment of 1 with 2-bromo-1-(naphtho[2,1-b]furan-2-yl)ethan-1-one (22) afforded imidazo[1,2-b][1,2,4]triazine derivative (23). The newly synthesized compounds were evaluated for their antimicrobial activities based on inhibition diameter zone against Gram positive and Gram negative bacteria.