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Paper | Regular issue | Vol 96, No. 10, 2018, pp.1759-1770
Published online, 28th September, 2018
DOI: 10.3987/COM-18-13968
One-Pot Synthesis of Isoindolin-1-ones from Nitroarenes and o-Phthalaldehyde via Indium-Mediated Reductive Condensation Reactions

Eungyung Kim, Mingyeong Jeong, Byung Min Lee, and Byeong Hyo Kim*

*Department of Chemistry, Kwangwoon University, 447-1, Wolgye-Dong Nowon-ku, Seoul, 139-701, Korea


Indium-mediated reductive condensation reactions of various nitroarenes with o-phthalaldehyde toward isoindolin-1-ones were investigated. In the presence of indium/AcOH in toluene at reflux, nitroarenes were coupled and cyclized with o-phthalaldehyde to produce corresponding isoindolin-1-ones with reasonable yields.