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Paper | Regular issue | Vol 96, No. 10, 2018, pp.1740-1749
Published online, 26th September, 2018
DOI: 10.3987/COM-18-13965
Protein-Promoted Synthesis of Chromene Derivatives via Biocatalytic Domino Reaction

Long-Hua Zhou,* Wei-Hua Huang, Li-Fang Ma, Yong-Jiu Jin, Fang Chen, and Yu-Ling Zhu

*Physical and Chemical Department, Nanchang Centre for Disease Control and Prevention, Lijing Road 833, Honggutan, Nanchang, 330038, China


An efficient and green procedure has been developed for the synthesis of chromenes using 1,3-diketones and ɑ,β-unsaturated aldehydes. The effect of reaction conditions including solvents, water content, molar ratio of substrates and catalyst loading were investigated. A series of chromene derivatives were prepared with moderate to high yields under the catalysis of bovine serum albumin (BSA) in isopropanol successfully. This novel activity of BSA to catalyze the domino reaction is not only of practical significance in expanding the application of biocatalysts, but also providing more convenient synthetic method for green chemistry.