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Communication | Special issue | Vol 99, No. 2, 2019, pp.865-874
Published online, 29th January, 2019
DOI: 10.3987/COM-18-S(F)93
Vicinal Functionalization of Uracil Heterocycles with Base Activation of Iodonium(III) Salts

Naoko Takenaga,* Shohei Ueda, Takumi Hayashi, Toshifumi Dohi, and Shinji Kitagaki

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan


We describe a new approach for the construction of bicyclic uracil systems and vicinal functionalization by utilizing uracil-iodonium(III) salts. Our method efficiently furnishes various multi-functionalized uracil derivatives in a single step.