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Short Paper | Regular issue | Vol 96, No. 9, 2018, pp.1631-1637
Published online, 15th August, 2018
DOI: 10.3987/COM-18-13958
Two New C19-Diterpenoid Alkaloids from Aconitum franchetii var. villosulum 

Wenliang Xu, Lin Chen, Feng Gao, and Xianli Zhou*

*School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China

Abstract

Two new C19-diterpenoid alkaloids, named villosudine A (1) and villosudine B (2), along with seven known diterpenoid alkaloids, were isolated from the root of Aconitum franchetii var. villosulum. Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, and HR-ESI-MS. Compounds (1-7) were evaluated for their cytotoxicity against the MCF-7 and HepG2 human cancer cell lines.