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Short Paper | Regular issue | Vol 96, No. 11, 2018, pp.1941-1957
Published online, 20th November, 2018
DOI: 10.3987/COM-18-13955
Synhesis, Molecular Docking Studies and in vitro Antimicrobial Evaluation of Novel Pyrimido[1,2-a]quinoxaline and Triazino[4,3-a]quinoxaline Derivatives

Rania B. Bakr,* Nadia A. A. Elkanzi, Amira A. Ghoneim, and Shaima M. N. Moustafa

*Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt


A series of 3-substituted-2,6-dihydro-1H-pyrimido[1,2-a]quinoxaline- 5-carboxylates (4a,b), (8c,d) and (13a,b) were prepared by treating ethyl 3-amino-1,4-dihydroquinoxaline-2-carboxylate (1) with alkylidenemalononitrile derivatives. Moreover, 8H-benzo[5,6][1,2,4]triazino[4,3-a]quinoxaline-7-carboxylate derivatives (18, 20, 22, 24) were synthesized from condensation reaction between diazonium salts 16 with resorcinol, 1-naphthol, malononitrile and ethyl acetoacetate respectively. Some of the newly synthesized compounds were screened for their antimicrobial activity studies. Furthermore, molecular docking were performed on the active compounds 1, 4a and 8c to predict the mode of action of these novel compounds.