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Short Paper | Regular issue | Vol 96, No. 8, 2018, pp.1445-1452
Published online, 6th July, 2018
DOI: 10.3987/COM-18-13939
An Efficient Construction of 9-(Guaiazulen-1-yl)xanthen-4(9H)-ones via Domino Reaction

Yu Liu, Jiao Xu,* Dao-Lin Wang,* Wei Ma, and Xing-Wei Zhang

*College of Chemistry and Chemical Engineering, Bohai University, 19, Keji Rd., New Songshan District, Jinzhou City, Liaoning Province 121001, China


A facile, convenient, and efficient synthesis of 9-(guaiazulen-1-yl)xanthen-4(9H)-one derivatives has been developed by the condensation of guaiazulene with salicylaldehyde, and 1,3-hexanediones in the presence of L-proline as the catalyst via the tandem Knoevenagel–Michael reaction.