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Paper | Regular issue | Vol 96, No. 7, 2018, pp.1226-1237
Published online, 28th June, 2018
DOI: 10.3987/COM-18-13934
Silver-Mediated 2-Arylation/Alkylation/Acylation of Benzothiazoles with Aldehydes in Water

Min Hua, Chunqin Wang, Qixing Liu,* Danyi Chen, Hao Fu, and Haifeng Zhou*

*Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China

Abstract

An efficient and environmentally benign method was developed for the facile synthesis of various 2-aryl and 2-alkyl substituted benzothiazoles in moderate to good yields, using a silver-mediated redox condensation of benzothiazoles and aldehydes in water. Furthermore, this method is also applicable to prepare 2-acyl benzothiazoles.