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Review | Regular issue | Vol 96, No. 11, 2018, pp.1869-1887
Published online, 19th September, 2018
DOI: 10.3987/REV-18-893
Synthesis, Reaction and Biological Activity of Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxides

Ghodsi Mohammadi Ziarani,* Manizheh Mostofi, Negar Lashgari,* and Mohammad Mahdavi

*Department of Chemistry, Alzahra University, Tehran, Iran


[1,2,4]Benzotriazine fused to pyrazole ring is a privileged heterocyclic scaffold present in numerous pharmacologically active compounds. Till date, various pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their deoxy analogues, possessing a broad spectrum of potent pharmacological activities, have been reported. In this review, we highlighted synthesis, chemical reactions, medicinal chemistry aspects and applications of fused pyrazole derivatives of [1,2,4]benzotriazine analogues reported so far.