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Paper | Special issue | Vol 99, No. 1, 2019, pp.213-221
Published online, 12th July, 2018
DOI: 10.3987/COM-18-S(F)11
New Indole Alkaloids from Ervatamia cumingiana

Mariko Kitajima, Shumpei Nakano, Noriyuki Kogure, Sanan Subhadhirasakul, and Hiromitsu Takayama*

*Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan


Two new Iboga-vobasine-type bisindole alkaloids N-demethylervahanine A (1) and N-demethylervahanine B (2) and one new chippiine-type alkaloid 3-O-methyl-10,11-demethoxychippiine (3) were isolated from the roots of Ervatamia cumingiana collected in Thailand. Their chemical structures were determined by spectroscopic analyses. Compounds 1 and 2 are bisindole alkaloids having a linkage between C-3 in the vobasine unit and C-11' or C-10' in the Iboga unit, respectively.