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Short Paper | Regular issue | Vol 96, No. 8, 2018, pp.1421-1429
Published online, 6th July, 2018
DOI: 10.3987/COM-18-13926
A Facile Synthesis of Indolo[2,3-b]carbazoles from the Reaction of Di(2-indolyl)methane and Aromatic Aldehydes Catalyzed by Oxalic Acid

Chun Li, Xunhua Lu, Yuanyong Yang, and Lin Zhang*

*Department of Pharmacy, Guizhou Medical University, No. 9, Beijing Road, Guiyang, 550014, China

Abstract

Oxalic acid catalyzed condensation of di(2-indolyl)methane with aromatic aldehydes has been established. Various indolo[2,3-b]carbazole derivatives were prepared in good isolated yields (up to 94.5%). Compared with literature methods, the present protocol features mild reaction conditions, easily controlled selectivity, good functional group tolerance, and simple operation procedures.