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Paper | Special issue | Vol 99, No. 1, 2019, pp.222-237
Published online, 12th December, 2018
DOI: 10.3987/COM-18-S(F)14
Exploration of Moderate Conditions and Substrate Variation in the Direct Condensation between Phthalide and Primary Amine Catalyzed by GaCl3. Are Aliphatic Amines Less Reactive than Aromatic Ones?

Ichiro Takahashi,* Yoshinori Nishiwaki, Kenta Saitoh, Takatoshi Matsunaga, Akihiro Aratake, Toshio Morita, and Shinzo Hosoi

*Department of Applied Chemistry and Biotechnology, Faculty of Engineering, University of Fukui, 9-1 Bunkyo 3-chome, Fukui-shi, 910-8507, Japan


Direct condensation between phthalide and a primary amine in the presence of Lewis acid was achieved for the first time in organic solvent-diluted reaction systems catalyzed by GaCl3. The peripheral aspects of this reaction is discussed.