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Short Paper | Regular issue | Vol 96, No. 6, 2018, pp.1119-1132
Published online, 21st May, 2018
DOI: 10.3987/COM-18-13907
Cinchona Alkaloid Thiourea Catalyzed Asymmetric Synthesis and Anticancer Activity Evaluation of Tetrahydro-β-spirooxindoles

Liang Qi, Huacui Hou, Fei Ling, Lu Fang, Wenjun Luo, and Weihui Zhong*

*Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, No.18 Chaowang Road, 6th Zhaohui District, Hangzhou, Zhejiang Province 310014, China


Asymmetric synthesis and activity evaluation of tetrahydro-β-spirooxindole compounds is reported in this paper. Cinchona alkaloid thiourea has been utilized as catalyst for the asymmetric synthesis of tetrahydro-β-spirooxindoles, affording the desired products in moderate to good yields and with up to 94:6 er. Interestingly, the spirooxindoles exhibited moderate to good in vitro antitumor activity for A549 cells. Besides, the growth inhibitory activities of these selected compounds against normal lung cell CHL cells were further evaluated.