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Review | Special issue | Vol 99, No. 1, 2019, pp.21-53
Published online, 27th February, 2019
DOI: 10.3987/REV-18-SR(F)1
Design and Synthesis of Artificial Ladder-Shaped Polyethers for Exploring Biological Functions

Tohru Oishi*

*Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan


Ladder-shaped polyethers (LSPs) are marine natural products produced by dinoflagellates. The unique molecular structure and interesting biological activities have attracted considerable attention of the synthetic community. On the other hand, artificial ladder-shaped polyethers (ALPs) have been designed and synthesized for exploring biological functions. In this review, design and synthesis of ALPs are summarized focusing on the development of synthetic strategies and methodologies.