Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Review | Regular issue | Vol 96, No. 8, 2018, pp.1335-1361
Published online, 8th May, 2018
DOI: 10.3987/REV-18-884
Synthesis of Nitrogen Containing Heterocycles by Using Carbon-Nitrogen Double Bond

Kentaro Okuma*

*Department of Chemistry, Faculty of Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan


Recent achievements in the construction of mainly nitrogen containing heterocycles by the intramolecular cyclization of alkenylanilides via activation of unsaturated bonds are reviewed. NIS or ZnX2 activation of 2-alkenylanilines and 2-alkynylanilines gave quinolines or indoles in high yields. Reaction of 2-aminobenzaldehyde with acetophenones under basic conditions gave dibenzonaphthyridines in one-pot operation. Other nitrogen and chalcogene containing heterocycles were also synthesized by the reaction of ketone hydrazones with chalcogen halides.