Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 96, No. 4, 2018, pp.707-715
Published online, 20th March, 2018
DOI: 10.3987/COM-18-13878
An Indocyanine-Based Turn-On Fluorescent Probe for Specific Detection of Biothiols

Xiaojing Wang, Di Jin, Xue Li, Xilong Yan,* and Bowei Wang*

*School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135#, Jinnan District 300350, Tianjin, China


A novel heptamethine cyanine-based turn-on fluorescent probe Cy-DNBS was designed and synthesized, which was used successfully to detect biothiols with high selectivity and sensitivity. With the addition of biothiols, the probe displayed ~30-fold fluorescence enhancement at 625 nm. Meanwhile, the solution color changed remarkably from green to red, which provides a method to recognize biothiols by the ‘naked eye’. The detection limit of Cys, GSH and Hcy are 2.24 nM, 1.99 nM and 4.46 nM, respectively.