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Paper | Regular issue | Vol 96, No. 4, 2018, pp.707-715
Published online, 20th March, 2018
DOI: 10.3987/COM-18-13878
An Indocyanine-Based Turn-On Fluorescent Probe for Specific Detection of Biothiols

Xiaojing Wang, Di Jin, Xue Li, Xilong Yan,* and Bowei Wang*

*School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135#, Jinnan District 300350, Tianjin, China

Abstract

A novel heptamethine cyanine-based turn-on fluorescent probe Cy-DNBS was designed and synthesized, which was used successfully to detect biothiols with high selectivity and sensitivity. With the addition of biothiols, the probe displayed ~30-fold fluorescence enhancement at 625 nm. Meanwhile, the solution color changed remarkably from green to red, which provides a method to recognize biothiols by the ‘naked eye’. The detection limit of Cys, GSH and Hcy are 2.24 nM, 1.99 nM and 4.46 nM, respectively.