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Review | Regular issue | Vol 96, No. 7, 2018, pp.1171-1196
Published online, 30th May, 2018
DOI: 10.3987/REV-18-882
■ Eudistomin U, Isoeudistomin U, and Related Indole Compounds: Synthesis and Biological Activity

Alexandra A. Kolodina and Olga V. Serdyuk*

*Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Nikolaus-Fiebiger-Str. 10, Erlangen 91058, Germany

Abstract

Eudistomin U and isoeudistomin U are important derivatives of β-carboline, tryptophan-derived metabolites. These natural products and related 2-substituted 1,2,3,4-tetrahydroeudistomins U demonstrate antibacterial, antimalarial, and anticancer activities, as well as a DNA-binding ability and strong KSP inhibition, that makes them very attractive targets for synthetic chemists. This manuscript highlights advances in the synthesis of eudistomin U, isoeudistomin U, their derivatives, and related compounds bearing an indole unit. A detailed discussion of biological activities, including structure-activity relationships, and future prospects, are also presented.