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Short Paper | Regular issue | Vol 96, No. 3, 2018, pp.518-525
Published online, 19th February, 2018
DOI: 10.3987/COM-18-13873
A Facile Ultrasound Assisted for an Efficient Synthesis of Imidazo[1,2-a]pyrazine-fused β-Carbolines

Yi-Xin Tang, Jiao Xu,* Wei Ma, Dao-Lin Wang,* and Liang Yan

*College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, China


An efficient tandem process for the synthesis of imidazo[1,2-a]pyrazine-fused β-carbolines is described. The construction of these compounds was achieved by three component reaction of 1H-indole-3-carbaldehyde, 2-aminopyrazine and trimethylsilyl cyanide via Groebke-Blackburn-Bienaymé reaction, followed by cyclization through the Pictet-Spengler reaction of the resulting 3-aminoimidazo[1,2-a]pyrazine which allowed access to the title heterocycles under ultrasound irradiation.