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Short Paper | Regular issue | Vol 96, No. 3, 2018, pp.509-517
Published online, 28th February, 2018
DOI: 10.3987/COM-18-13872
A Simple Method for Synthesis of Thioamides and Application in Synthesis of 1,2,4-Thiadiazoles

XianTing Cao, HuiYong Yang, Hui Zheng, and PengFei Zhang*

*College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China


A novel, simple protocol is disclosed for the synthesis of 1,2,4-thiadiazoles starting from thioamides with Na2-eosin Y-sensitized titanium dioxide as catalyst through visible light irradiation (7 W blue LED light) and only 0.3 mol% catalysts were used. The raw material thioamides is prepared by aryl nitriles and sodium sulfide (Na2S·9H2O) in DMF and in this reaction, readily available, inexpensive inorganic salt (Na2S·9H2O) serves as the sulfur source and various functional groups of aryl nitriles were well and thioamides were synthesized successfully in gram-scale.