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Short Paper | Regular issue | Vol 96, No. 3, 2018, pp.501-508
Published online, 2nd March, 2018
DOI: 10.3987/COM-18-13867
Brønsted Acid-Promoted Multicomponent Reaction for the Construction of Pyrrolocoumarin Derivatives

Zhiwei Chen,* Sunjia Ye, and Xiongfei Zhang

*Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China


An efficient one-pot synthesis of functionalized indole-containing pyrrolocoumarin derivatives via a three-component reaction of 4-aminocoumarins, arylglyoxal monohydrates and indoles promoted by p-TSA in ethanol is described. The attractive features of this protocol are simple starting materials, operational simplicity, short reaction time and moderate to good yields.