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Short Paper | Regular issue | Vol 96, No. 4, 2018, pp.749-756
Published online, 7th March, 2018
DOI: 10.3987/COM-18-13869
New Bromoindole Alkaloid Isolated from the Marine Sponge Hyrtios erectus

Alaa A. Bagalagel, Hanin A. Bogari, Safwat A. Ahmed, Reem M. Diri, and Sameh S. Elhady*

*Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Abstract

5’-[(6-Bromo-1H-indol-3-yl)methyl]-3’-methylimidazolidine-2’,4’-dione (1), a new bromoindole alkaloid was derived from the marine sponge Hyrtios erectus (order Dictyoceratida) collected in the Red Sea. Additionally, two known indole alkaloids (23) were also isolated. The chemical structures of the isolated compounds were elucidated on the basis of detailed spectroscopic analysis as well as comparison with published data. Compound 1 showed weak antiproliferative activity against colorectal carcinoma (HCT-116), breast adenocarcinoma cells (MCF-7) and hepatocellular carcinoma (HepG2). Additionally, at concentration of 3 mg/mL, compound 1 displayed moderate antibacterial activity against S. aureus and E. coli.