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Short Paper | Regular issue | Vol 96, No. 2, 2018, pp.334-338
Published online, 23rd January, 2018
DOI: 10.3987/COM-17-13859
An Efficient Synthesis of 1-Hydroxy-5,8-dimethoxy-2-naphthaldehyde

Qijing Zhang, Jinyun Dong, Guang Huang, and Shaoshun Li*

*School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Shanghai 200240, China


An efficient method for the preparation of 1-hydroxy-5, 8-dimethoxy-2-naphthaldehyde (1) was developed with a high overall yield (73.8%). Compared with the previously reported method, the reaction conditions are milder and the work-up of each step is much simpler. Moreover, the starting material considerably reduces the cost and is suitable for large-scale preparations.