Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 96, No. 2, 2018, pp.233-253
Published online, 15th January, 2018
DOI: 10.3987/COM-17-13844
One-Pot Three-Component Synthesis of Novel Pyrazole-2,3-pyrroledicarboxylic Acid 2,3-Diesters

Emi Shirouzu, Eiichi Masumoto, Fumi Okabe-Nakahara, Kenji Yamagata, and Hiroshi Maruoka*

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Abstract

A facile synthesis of a series of pyrazol-3-one derivatives containing dihydropyrrole moiety using an efficient three-component reaction with 4-(dicyanomethylene)-3H-pyrazol-3-ones, acetylenic esters, and anilines is reported. The reaction is moderate to good yielding, tolerant towards a variety of amines, and provides access to novel pyrazole-2,3-pyrroledicarboxylic acid 2,3-diesters in a single step. All the synthesized compounds were characterized by spectroscopic analysis.