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Short Paper | Regular issue | Vol 96, No. 2, 2018, pp.297-303
Published online, 17th January, 2018
DOI: 10.3987/COM-17-13847
Sulfanilic Acid-Catalyzed Green Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones

Hamzeh Kiyani* and Shiva Aslanpour

*School of Chemistry, Damghan University, 36719-41167 Damghan, Iran


This study is focused on the catalytic activity of sulfanilic acid (SA) in the straightforward synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones via condensation of aromatic aldehydes, hippuric acid, and acetic anhydride under green experimental conditions (water solvent). The catalyst could be recovered easily from the filtrate via evaporation of the solvent and reused many times. It was found that the method is clean, relatively rapid, and environmentally friendliness alternative for the synthesis of Erlenmeyer-Plöchl azlactones as well as no needed for heating, microwave and ultrasound irradiations. Furthermore, all of the substrates and catalyst are easily accessible and inexpensive.