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Short Paper | Regular issue | Vol 96, No. 3, 2018, pp.461-469
Published online, 15th February, 2018
DOI: 10.3987/COM-17-13839
Synthesis of the Anti-Prostate Cancer Drug Abiraterone Acetate

Siyue Ma, Jianheng Li,* Huayang Tang, and Feng Xu

*School of Pharmacy, Hebei University, No.180 WuSi Road, Baoding, 071002, China


Abiraterone acetate is used for the treatment of castration-resistant prostate cancer. Abiraterone acetate was synthesized from dehydroepiandrosterone via a three-step reaction including the formation of tosylhydrazone, cross-coupling reaction and acetylation, and a two-step purification including column chromatography and recrystallization with an overall yield of 51.9%. Here, an improved procedure for the preparation of abiraterone acetate is described. This synthetic process is of easy operation and low cost, which is suitable for industrialization.